Multiple genes behind schizophrenia in
10 September 2002
US scientists have found that even in the most remote populations, schizophrenia
is associated with multiple genes.
William Byerley (University of California, Irvine) and colleagues investigated
the genetic basis of schizophrenia in the geographically and culturally
isolated population of Palau in Micronesia.
Using markers every 10 centimorgans (cM), the researchers genotyped five,
large multigenerational schizophrenia pedigrees, and found the number
of affected/unaffected individuals in each family varied from 11/21 to
Fitting a simple dominant and recessive model to the data, the team were
able to calculate a substantial logarithm of odds (LOD) score for each
family. A LOD score of above 3 indicates that two loci are close together
on a chromosome and are likely to be inherited together.
"Predictably, the most informative pedigrees produced the best linkage
results," the scientists comment>Early Schizophrenia Screening Test
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