July 07, 2004
Antipsychotic Iloperidone in Development
Iloperidone is a novel antipsychotic currently in Phase III clinical trials. It has been shown to selectively block subsets of human dopamine, serotonin, and norepinephrine receptors. Early results suggest that iloperidone may be able to treat a broad range of positive, negative, depressive, and cognitive symptoms of schizophenria, with a low incidence of side effects.
The following is Titan Pharma's Marketing/Press release acquired from Titan Pharmaceuticals (http://www.titanpharm.com/press/IloperidoneLicense.htm). Originally released June 9, 2004
Titan Pharmaceuticals, Inc. (ASE:TTP) today announced that Vanda Pharmaceuticals, Inc. has acquired the worldwide rights to develop and commercialize iloperidone, Titan?s proprietary antipsychotic agent in Phase III clinical development for the treatment of schizophrenia and related disorders, from Novartis Pharma AG. Vanda is a pharmaceutical development company headquartered in Rockville, Maryland, founded by its Chairman, Dr. Argeris N. Karabelas, formerly CEO of Novartis Pharmaceuticals, and its CEO, Dr. Mihael Polymeropoulos, former Vice President of Pharmacogenetics at Novartis Pharmaceuticals. Under the license agreement from Novartis, Vanda will pursue completion of the iloperidone Phase III development program and product registration. All of Titan?s rights and economic interests in iloperidone, including royalties on sales of iloperidone, remain unchanged under the license agreement.
"We are very pleased that Vanda will now move forward to continue Phase III clinical testing of iloperidone," stated Dr. Louis R. Bucalo, Chairman, President and CEO of Titan. "We believe Vanda has the expertise to pursue the successful completion of iloperidone development. With the implementation of this agreement," continued Dr. Bucalo, "Titan re-establishes an important Phase III clinical program, and now has six proprietary products in clinical testing."
Approximately 1% of the world?s population, 45 million people in total, suffer from schizophrenia. Many patients also suffer from difficult side effects, including significant weight gain, movement disorders and cognitive dysfunction from current therapies.
About Titan Pharmaceuticals
TITAN PHARMACEUTICALS, INC. (ASE: TTP) is a biopharmaceutical company focused on the development and commercialization of novel treatments for central nervous system disorders, cancer and cardiovascular disease. Titan?s numerous products in development utilize novel technologies that have the potential to significantly improve the treatment of these diseases. Titan also establishes partnerships with multinational pharmaceutical companies and government institutions for the development of its products.
Posted by Julia at July 7, 2004 05:06 PM
More Information on Schizophrenia Medications
Iloperidone was dropped by Novartis quite a while ago because of concerns about heart QT elongation among other concerns. The medicine was also going to be called Zomaril.
A year of so after Novartis dropped out, Vanda, a new company, declared that it would pursue this medicines development in the USA....Robert
Posted by: Robert at July 10, 2004 09:28 PM
me gustar�a saber que pasa con este remedio y los efectos piramidales y si es para esquizoafectivos y resultados.
Posted by: cristina larrain at July 13, 2004 04:58 PM
There is a ignored problem of schizophrenia
treatment that may have some potential in research. "The mental health symptoms that occur
when coffee is consumed by schizophrenics"
Th uptake of caffiene on a daliy basis can cause
delusions, and hallucinations in schizophrenics on
a low, or moderate dosage of psychiatric medication. It seems schizophrenics have the
reverse problem of drug addicts. Drug addicts
can return to normal if they stop using drugs
for several months. Schizophrenics become mental,
on excess dopamine in the brain after several
months. It would appear a pill that could
moderate, or cancel the absorbtion on caffiene
intake in the human body, might help schizophrenics who drink coffee.
Sometimes I wonder if schizophrenia can be treated
by controling the uptake by the body of stimulants
in food, and beverages.
Posted by: Ken at July 19, 2004 06:00 PM
Please considera our contry, Lima, Peru to allow our ill relatives to try your med.
Posted by: mirtha gonzalez at July 22, 2004 07:09 PM
I would like information about clinical studies for this new medication. Is your company looking for volunteers? Also, is it known how this new drug would be affected by the patient who consumes alcohol? Would you be willing to test a skizophrenic patient who is also alcohol dependent?
Posted by: sharon at August 4, 2004 06:45 AM
I AM SCHIZOAFFECTIVE-BIPOLAR TYPE. I'M ON 2 DIFFERENT ANTIPSYCHOTICS, AND WOULD BE VERY INTERESTED IN TRYING ILOPERIDONE. WHAT WOULD I NEED TO DO TO QUALIFY FOR A TRIAL? I WORRY ABOUT TARDIVE DYSKENESIA FROM MY PROLIXIN, BUT IT HELPS THE POSITIVE SYPTOMS, THE ABILIFY SOMEWHAT HELPS THE NEGATIVES. I ALREADY GAINED 75 POUNDS FROM 3 YEARS ON SEROQUEL. I'VE TRIED JUST ABOUT EVERYTHING, AND I GUESS I'M HOPING THIS MAY BE MY MIRACLE.
Posted by: Della at August 7, 2004 02:43 AM
I WAS INTERESTED IN GETTING INTO A STUDY WITH YOUR NEW ANTIPSYCHOTIC ILOPERIDONE. I HAVE BEEN ON MANY ANTIPSYCHOTICS, AND HAVE MEDIUM RESULTS. I AM SCHIZOAFFECTIVE-BIPOLAR TYPE. I CURRENTLY TAKE PROLIXIN AND ABILIFY. THANK YOU
Posted by: DELLA at August 7, 2004 02:55 AM
Quisiera recibir informaci�n acerca de Iloperidone en especial en relaci�n a experimentaci�n en mi pa�s. Cu�l es el laboratorio que promueve su utilizaci�n - Novartis? -, en cuantos centros de rehabilitaci�n se emplea. Cu�les son las diferencias a grandes rasgos con el Haloperidol
Posted by: virginia bravo at August 14, 2004 11:51 PM
What is currently being used successfully for Tardive dyskinesia?
Posted by: Rebecca at October 18, 2006 08:18 AM
We need an anti- Tardive Dyskinesia neuraleptic; if this is it, where do I sign up?
Posted by: henry at February 14, 2007 02:57 PM
I would like to try iloperidone. I am married and I am schizoaffective depressive type and I am on Risperidal now. I am tired of the side effects of my current medication.
I read that iloperidone dose not affect the level of prolactine.
How could I sign up to try it ?
Posted by: Piotr Przybylski at March 29, 2007 05:02 PM
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