October 12, 2005

Topiramate add-on in treatment-resistant schizophrenia

Cross-over trial of topiramate add-on for treatment-resistant schizophrenia

A new study on Topiramate suggests:

* Topiramate 300 mg/day improves general but not positive/negative psychotic symptoms

* Topiramate could have value for ameliorating depressive symptoms

The results of a cross-over trial published in the Journal of Clinical Psychiatry confirmed the hypothesis that topiramate may be an effective adjuvant treatment for those with treatment-resistant schizophrenia. In this randomized, double-blind trial, topiramate showed significant advantage over placebo in reducing general psychotic symptoms, although no significant improvement was seen in positive or negative symptoms.

The study authors note that the greatest reductions with topiramate vs. placebo were observed in the general psychopathologic symptoms of depression (PANSS item G6), preoccupation (item G15) and guilt feelings (G3). They suggest that the therapeutic effect of topiramate may differ from that of lamotrigine, which has shown benefits for both positive and general psychopathologic symptoms in schizophrenia (Tiihonen, 2003 & Kremer, 2004).

The authors conclude, "Although pharmacologic studies generally focus on the change in positive and negative symptoms, it has been observed that depressive symptoms ... contribute more to the quality of life of schizophrenic patients ... Therefore, topiramate add-on treatment may improve the quality of life in a sub-group of chronically seriously ill patients suffering from general psychopathologic symptoms such as depression." Due to the limitation of a small sample size, the authors add that their results must be considered preliminary.

The Study was funded by non-industry sources.

Tiihonen J, Halonen P, Wahlbeck K, et al.: Topiramate add-on in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled crossover trial. J Clin Psychiatry 2005; 66(8): 1012-1015


topiramate add on treatment
A very useful information.But it attenuates the efficacy of anti/psychotic medication and so the dosage has to be adjusted in a careful way.It is also very helpful in condition of addiction in some schizophrenics like for some food stuffs,colas,cigarettes,alcohol etc.But it has serious sideffect like increased IOP which has to be monitored.

Posted by: captain johann at October 25, 2005 06:51 AM

Thanks for a beautiful site! I have added you in elected!
Necessarily I shall advise your site to the friends!
Best wishes for you!the astroforecast

Posted by: Lohness at June 19, 2008 03:37 PM

Post a comment

Please enter this code to enable your comment -
Remember Me?
(you may use HTML tags for style)
* indicates required