January 13, 2006

Mitochondrial DNA is abnormal in bipolar disorder and schizophrenia

A New Study suggests that Maintenance of mitochondrial DNA is abnormal in bipolar disorder and schizophrenia

A new resesarch report out of Japan has reported that there are unusual mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia. "Several clinical, genetic and neuroimaging studies implicate mitochondrial dysfunction in the pathophysiology of bipolar disorder and schizophrenia.

The report stated that:

"A lack of normal age-related accumulation of this deletion in schizophrenia and increased occurrence of the common deletion in bipolar disorder have been reported," wrote C. Kakiuchi and colleagues, RIKEN.

"However, even in the affected bipolar samples, the levels of common deletion were relatively small, indicating that the common deletion did not play a pathophysiological role in respiratory function. We hypothesized that accumulation of multiple mtDNA deletions, rather than the common deletion alone, is involved in the pathophysiology of these two major mental disorders."

"We observed no association between mtDNA deletions and the two major mental disorders in the frontal cortex, which did not support our hypothesis. We did, however, make the following observations, although they were not significant after Bonferroni correction: (1) the ratio of mtDNA to nuclear DNA was significantly higher in female patients with schizophrenia than in control females (p=.040), and (2) in bipolar disorder, the relative amount of mtDNA decreased with age (p=.016)."

They concluded, "Our results suggest that abnormalities in the system maintaining replication of mtDNA may underlie bipolar disorder and schizophrenia."

Source: (Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia. Int J Neuropsychopharmacol, 2005;8(4):515-522).


My sister has been sexually abused. And the doctor put her on medications for manic/bipolar and schizophrenia medications like geodon, effexor( i think thats gow you spell it) and nirovan. But she still has problems. Sometimes I can not understand a word thats coming out of her mouth. Its like little clues. Should I get her another opinon. My Mother was also an abuser. But yet I have no symptoms like this.

Posted by: Dorothie at June 22, 2006 12:02 PM

Has anyone responded to you? Been there, doing that. I would get another,and another until a doctor you and your sister trust get the meds correct. It's hard. Effexor is a big no-no. Cymbalta is worse. Ambilify and a few others are worth a try. Hang in there. Respond if you want.
Steph. Age 44 w/husband &kids.

Posted by: Steph at November 8, 2006 06:17 PM

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