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June 12, 2006
Neurodevelopment and Schizophrenia
There is a book that come out a few years back, published by Cambridge Press in 2004 - that is titled, appropriately "Neurodevelopment and schizophrenia".
As it happens - the famous Dr. Frederick Freese (a board member of NAMI and person who has recovered from schizophrenia to become a noted psychologist and professor) has recently reviewed this book - and while its written for psychologists and advanced students of psychiatry - both the review and the book has valuable information.
Dr. Freese notes, in his review:
"Some of the book's 24 chapters are particularly relevant for consumers and practicing clinicians. In Chapter 9, Sahebarao P. Mahadik covers recent findings concerning schizophrenia and nutrition. He makes very compelling arguments for including omega-3 essential polyunsaturated fatty acids and antioxidants, such as vitamins E and C, in the dietary intake of virtually all persons with schizophrenia.
Read the full book review here: Neurodevelopment and Schizophrenia.
You can purchase the book at amazon.com - here: Neurodevelopment and Schizophrenia
As it happens, we have a copy of the book in our library - and so have included a short excerpt of the Foreward of the book to provide a better overview of what is covered.
Although both Kraepelin and Bleuler noted that premorbid abnormalities in child-hood could be present many years before a schizophrenic psychosis developed (Marenco and Weinberger, 2000), until the late 1980s and 1990s, most people viewed schizophrenia as an adult-onset mental illness. As a result, most biological studies focused on a search for possible neurodegenerative changes that might account for the onset of the condition. During the 1960s and 1970s (see Garmezy, 1974; Offord and Cross, 1969), evidence began to accumulate from developmentally oriented follow-up and follow-back studies that abnormalities in interpersonal relationships, neurodevelopmental immaturities, and attentional deficits in child-hood all predicted the later onset of schizophrenia (see Rutter and Garmezy, 1983). However, it was not until 1987 (Murray and Lewis, 1987; Weinberger, 1987) that psychiatrists concerned with adult patients firmly took on board the notion that schizophrenia might be a neurodevelopmental disorder. Since then, there has been a veritable explosion of research tackling this proposition using a variety of research strategies. In parallel, there has been an upsurge in studies of brain development and function, giving rise to a much evident that there are important neural changes that extend into late adolescence and early adult life.
The table of contents of the book is as follows:
Each chapter is essentially a short review article that covers the results of a number of studies in a given area. Its excellent information - but enrollment in a medical school is probably a prerequisite for successful understanding of the entire book.
1. Genes and brain development - Timothy A. Klempan, Pierandrea Muglia and James L. Kennedy;
2. Brain development in healthy children and adolescents: magnetic resonance imaging studies - Jay N. Giedd, Michael A. Rosenthal, A. Blythe Rose, Jonathan D. Blumenthal, Elizabeth Molloy, Richard R. Dopp, Liv S. Clasen, Daniel J. Fridberg and Nitin Gogtay;
3. Cognitive development: fMRI studies - Beatriz Luna and John Sweeney;
4. Cognitive development in adolescence: cerebral underpinnings, neural trajectories and the impact of aberrations - Stephen J. Wood, Cinzia R. DeLuca, Vicki Anderson and Christos Pantelis;
5. Brain plasticity and long-term function after early cerebral insult: the example of very preterm birth - Matthew Allin, Chiara Nosarti, Larry Rifkin and Robin M. Murray;
6. Do degenerative changes operate across diagnostic boundaries? The case for glucocorticoids involvement in major psychiatric disorders - Carmine M. Pariante and David Cotter;
7. Velo-cardio-facial syndrome (deletion 22q11.2): a homogeneous neurodevelopmental model for schizophrenia - Stephan Eliez and Carl Feinstein;
8. Can structural MRI provide an alternative phenotype for genetic studies of schizophrenia? - Colm McDonald and Robin M. Murray;
9. Nutritional factors and schizophrenia - Sahebarao P. Mahadik;
10. Schizophrenia, neurodevelopment, and epigenetics - Arturas Petronis;
11. Early environmental risk factors for schizophrenia - Mary Cannon, Kimberlie Dean and Peter B. Jones;
12. Transcriptomes in schizophrenia: assessing altered gene expression with microarrays - David A. Lewis, Karoly Mirnics and Pat Levitt;
13. Is there a role for social factors in a comprehensive development model for schizophrenia? - Jane Boydell, Jim Van Os and Robin M. Murray;
14. How does drug abuse interact with familial and developmental factors in the aetiology of schizophrenia? - Chih-Ken Chen and Robin M. Murray;
15. Developmental dysregulation of the dopamine system and the pathophysiology of schizophrenia - Anthony A. Grace;
16. The development of ‘mis-wired’ limbic lobe circuitry in schizophrenia and bipolar disorder - Francine M. Benes;
17. Development of thalamocortical circuitry and the pathophysiology of schizophrenia - Darlene S. Melchitzky and David A. Lewis;
18. X chromosome, estrogen, and brain development, implications for schizophrenia - Michael Craig, William Cutter, Ray Norbury and Declan Murphy;
19. Premorbid structural abnormalities in schizophrenia - Stephen M. Lawrie;
20. Neurodegenerative models of schizophrenia - L. Fredrik Jarskog, John H. Gilmore and Jeffrey A. Lieberman;
21. Does disordered brain development cut across diagnostic boundaries? - Christian W. Kreipke, David R. Rosenberg and Matcheri S. Keshavan;
22. Can one identify preschizophrenic children? - Eugenia Kravariti, Paola Dazzan, Paul Fearon and Robin M. Murray;
23. High risk studies, brain development and schizophrenia - Matcheri S. Keshavan;
24. Developmental models and hypotheses-driven early interventions in schizophrenia - Matcheri S. Keshavan and Barbara A. Cornblatt.
Posted by szadmin at June 12, 2006 02:52 PM
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