July 24, 2006

Astra Zeneca submits New Drug Application for Sustained Release Seroquel

Schizophrenia.com member Rcourtade noted that on July 18th it was announced that AstraZeneca had submitted a New Drug Application (NDA) to the US Food and Drug Administration for a sustained release (SR) once-daily formulation of Seroquel for the treatment of patients with schizophrenia.

The clinical trials to support the US submission of Seroquel SRTM used a short titration period aimed at achieving a therapeutically effective dose by the second day of treatment. The Company also expects to make a Seroquel SRTM filing in the European Union towards the end of 2006. The SR formulation has patent protection to 2017.

It appears that a number of the major drug companies will soon have sustained released versions of their antipsychotic medications available. Janssen is working on their version of SR Risperdal (that they are calling Paliperidone. Other pharma companies have filed patents for oral liquid versions of their medications as well, and a version of Pfizer's Geodon is also expected in an intramuscular injection version sometime in 2007 suggested AdMed news this month.


Thats fantastic, but people are already taking seroquel once daily? anyways its all great news to hear about meds being developed to assist people with SZ.
Thanks Rcourtade for the excellent information.
Kind Regards,

Posted by: grinspoon at July 31, 2006 12:22 AM

Just done some reading up and its going to be slow release, AWESOME news.

Posted by: grinspoon at July 31, 2006 12:24 AM


Good to hear that progress is being made on seroquel. The seroquel I take however, knocks me out for the night and I'm only available again in the morning. So does sustained release mean that I sleep all day and night? Or does it mean that I get to be chilled most of the day, and sleep when I want? Personally sustained release seroquel sounds a like zombification technique, if I know seroquel.


Posted by: Douwe Bijker at August 1, 2006 01:51 AM

Thats a great point Douwe, Seroquel also knocks me about sometimes and looking at it now with the slow release, I am thinking along the same lines if it will take away activity and replace it with tiredness.

Posted by: grinspoon at August 2, 2006 10:07 PM

the idea with the time release seroquel is it would both last longer, and stop the oh-i-just-took-my-seroquel-ZZZZZZ feeling.

people do now take seroquel once a day, but often they take it at night to quell increasing night symptoms ('sundowning') that prevent sleep.

in 7 hrs, th present seroquel is down to about a half of its initial level, and then fades very quickly after that. for people that use it as their mainstay antipsychotic, that often means they need to take it 2-3 times a day to get symptom control.

this time release med should do several things. it should make people feel less knocked out when they first take it, and it should also increase the time period over which it works, making 2-3 times a day remembering to take medication unneccessary.

for some people, seroquel, even in the time release form, will remain too antihistiminey (i think that's not a word), but for a great many people, it's going to make their medication taking much more pleasant.

Posted by: slc2 at August 4, 2006 08:46 AM

I was just prescribed seroquel for social phobia, general anxiety, and bi-polar disorder at a dosage og 200mg twice a day. Is this a lot to take at once because the first time I took it I slept for more than 48 hours. And woke up feeling drunk.BTW I am also taking xanax xr and lamictil could that have had an effect, and I am decreasing my dosage of effexor as I increase the lamictil.

Posted by: REDZERO at April 9, 2007 11:51 PM

I just have been prescribes the new seraquel,"Time released becuz iv been hearing auditory
hallucination, I'm am taking 500 mg of seraquel as of right now and lamictel and buspar , How will this interact with my other meds will it help with the hallucination??!?!?!?!

Posted by: Law at December 11, 2007 03:03 PM

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