February 10, 2007

Cannabis Abuse May Lead to Earlier Schizophrenia Onset, Worse Outcome

In Current Psychiatry Online, Dr. Joseph M. Rey, MD, PhD discusses the growing evidence showing that marijuana (cannabis) use can not only cause acute psychosis, but also hasten the onset of schizophrenia (bringing forward in time a first schizophrenia episode), and worsen the outcome of patients with psychotic disorders.

Dr. Rey clearly explains many recent discoveries about marijuana use including the genetic catechol-O-methyltransferase (COMT) variability precipitating psychotic disorders when marijuana abuse is started in adolescence, an association not seen when the marijuana use is started later in life.

Other risk factors mentioned for developing a schizophrenia-spectrum illness from marijuana use include a family history of psychosis, frequent use, or having unusual or psychotic-like experiences from the marijuana.

Read the complete article: Does marijuana contribute to psychotic illness?

Additional Reading:

Marijuana Causal Links to Schizophrenia

Cannabis and Psychosis (schizophrenia) and the COMT gene
Cannabis and Psychosis (schizophrenia) Update
Marijuana induced psychosis foretells future episodes


This is quite alarming since I know many of my peers who are into marijuana. I never thought this can be related to dual disorders.Thanks for this article


Posted by: Dual Disorder at March 9, 2007 04:41 AM

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