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June 29, 2007
Antipsychotics, Schizophrenia and Diabetes Care
Read more... Schizophrenia Med Side-effects
On Medscape Psychiatry, Dr. C. Lindsay DeVane (PharmD), incorporating the latest research, gives a nice summary and discussion about Type 2 diabetes, schizophrenia, and the use of atypical antipsychotics.
With a reminder that although there may be an increased incidence of diabetes among people with schizophrenia regardless of antipsychotic use, the use of atypical antipsychotics also carries an increased risk of reduced insulin sensitivity (a factor in development of type 2 diabetes) even in the absence of weight gain. In addition, some atypical antipsychotics cause significant weight gain in some people and that, too, increases diabetes risk.
Therefore, a consensus panel of experts representing endocrinologists and psychiatrists published recommendations for monitoring of patients receiving atypical antipsychotics.
A list of atypical antipsychotics ranked by greatest to the least general risk of metabolic effects was given as olanzapine, quetiapine, risperidone, ziprasidone, and aripiprazole, with a reminder that even this ranking is not necessarily true for any particular individual.
What is important for all individuals taking any of these medications, is that they be carefully monitored for metabolic side-effects and risk for developing diabetes, and that they be treated for such a risk or the actual development of type 2 diabetes.
Treatment includes dietary management, regular physical activity, medications to control blood glucose, and sometimes switching antipsychotics.
Posted by Jeanie Wolfson at June 29, 2007 06:45 AM
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